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Molecular Survey of Hepatitis C Virus in the Touristic City of Mar Del Plata Argentina

机译:在旅游城市马德普拉塔阿根廷的丙型肝炎病毒的分子调查

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摘要

The global epidemiology of Hepatitis C Virus (HCV) may be roughly described by two groups of genotypes: the worldwide distributed ones (subtypes 1a, 1b, 2a and 3a, among others) and the endemic ones (subtypes 4a, 5a, 6a, among others). Epidemiological and population dynamic studies of the worldwide distributed genotypes have shown that subtypes 1a and 3a are common among intravenous drug users (IDUs) and that they are also in expansion in some countries. The molecular survey of HCV provides some clues about the epidemiological status of the infections in a local scale and the phylogenetic and demographic reconstruction analyses complement this study by inferring whether the infections of certain subtypes are in a steady state or expanding. Here, a molecular survey of the HCV variants that circulate in the touristic city of Mar del Plata (Buenos Aires, Argentina) was performed in samples obtained from 42 patients. The subtypes detected were 1a (32 patients), 3a (8 patients) and 1b (2 patients). The demographic history of subtype 1a inferred using the sequence data showed an exponential growth in the 1990′s. The period of viral expansion was delayed compared with that observed for the same genotype in other countries where the transmission was associated with IDUs. Also, the phylogeographic analysis of HCV-1a showed a statistically significant association between the location of the samples and the phylogeny, which may be the result of the local transmission of HCV in the city. The molecular analysis helped in the description of the complex epidemiological context of a touristic city, and pointed out that some sanitary measures should be taken in order to reduce the transmission of HCV (and maybe of HIV) among IDUs.
机译:丙型肝炎病毒(HCV)的全球流行病学可以通过两类基因型进行大致描述:全球分布的基因型(亚型1a,1b,2a和3a等)和地方性基因型(亚型4a,5a,6a等)其他)。全球分布基因型的流行病学和人口动态研究表明,亚型1a和3a在静脉吸毒者(IDU)中很常见,并且在某些国家也正在扩大。 HCV的分子调查为局部感染的流行病学状况提供了一些线索,系统发育和人口统计重建分析通过推断某些亚型的感染是处于稳定状态还是正在扩展而补充了该研究。在这里,对从42名患者中采集的样本,在旅游城市马德普拉塔(阿根廷布宜诺斯艾利斯)传播的HCV变异分子进行了分子调查。检测到的亚型为1a(32例),3a(8例)和1b(2例)。使用序列数据推断的亚型1a的人口统计学历史表明,在1990年代呈指数增长。与在其他传播途径与注射毒品相关的国家中观察到的相同基因型相比,病毒的扩张期被延迟了。此外,HCV-1a的系统地理分析表明,样本位置与系统发育之间存在统计学上的显着关联,这可能是城市中HCV局部传播的结果。分子分析有助于描述一个旅游城市的复杂流行病学背景,并指出应采取一些卫生措施,以减少丙肝病毒(也许是艾滋病毒)在注射毒品使用者之间的传播。

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