Safety and Feasibility of Topical Application of Limonene as a Massage Oil to the Breast

摘要

BackgroundLimonene, a major component in citrus oil, has demonstrated anti-cancer effects in preclinical mammary cancer models. However, the effective oral dose translates to a human dose that may not be feasible for chronic dosing. We proposed to evaluate topical application of limonene to the breast as an alternative dosing strategy.