Synthesis and evaluation of new radioligands 11CA-833834 and 11CA-752274 for positron-emission tomography of α7-nicotinic acetylcholine receptors

摘要

Introductionα7-nicotinic acetylcholine receptor (α7-nAChR) is one of the major neuronal nAChR subtypes. α7-nAChR is involved in variety of neuronal processes and disorders including schizophrenia and Alzheimer’s disease. A number of α7-nAChR PET radioligands have been developed, but a quality radiotracer remains to be discovered.