Equivalence of Arterial and Venous Blood for 11CCO2-Metabolite Analysis Following Intravenous Administration of 1-11CAcetate and 1-11CPalmitate

摘要

PurposeSampling of arterial blood for metabolite correction is often required to define a true radiotracer input function in quantitative modeling of PET data. However, arterial puncture for blood sampling is often undesirable. To establish whether venous blood could substitute for arterial blood in metabolite analysis for quantitative PET studies with 1-[¹¹C]acetate and 1-[¹¹C]palmitate, we compared the results of [¹¹C]CO2-metabolite analyses performed on simultaneously collected arterial and venous blood samples.