On the need for comprehensive validation of deformable image registration investigated with a novel 3D deformable dosimeter

摘要

PurposeDeformable image registration (DIR) algorithms may enable multi-fraction dose tracking and improved treatment response assessment, but the accuracy of these methods must be investigated. This study introduces and evaluates a novel deformable 3D dosimetry system (Presage-Def/Optical-CT) and its application toward investigating the accuracy of dose deformation in a commercial DIR package.