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GLYX-13 an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

机译：GLYX-13一种NMDA受体甘氨酸位点功能性局部激动剂可增强认知并产生抗抑郁作用而无NMDA受体拮抗剂的拟精神病副作用

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IntroductionThe N-methyl-d-aspartate receptor-ionophore complex plays a key role in learning and memory and has efficacy in animals and humans with affective disorders. GLYX-13 is an N-methyl-d-aspartate receptor (NMDAR) glycine-site functional partial agonist and cognitive enhancer that also shows rapid antidepressant activity without psychotomimetic side effects.

机译：简介N-甲基-d-天冬氨酸受体-离子载体复合物在学习和记忆中起关键作用，并在患有情感障碍的动物和人类中具有功效。 GLYX-13是一种N-甲基-d-天冬氨酸受体（NMDAR）甘氨酸位点功能性局部激动剂和认知增强剂，它还显示出快速的抗抑郁活性，没有拟精神病药物的副作用。

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期刊名称 other
作者
Joseph R Moskal; Ronald Burch; Jeffrey S Burgdorf; Roger A Kroes; Patric K Stanton; John F Disterhoft; J David Leander;
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作者单位

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年(卷),期 -1(23),2
年度 -1
页码 243–254
总页数 22
原文格式 PDF
正文语种
中图分类
关键词
antidepressant depression glycine site major depressive disorder NMDA receptor rapid-acting;

机译：抗抑郁药;抑郁症;甘氨酸部位;严重抑郁症;NMDA受体;快速作用;

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1. GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists [J] . MoskalJ.R., BurchR., BurgdorfJ.S., Expert opinion on investigational drugs . 2014,第2期

机译：NMDA受体甘氨酸位点功能性部分激动剂GLYX-13增强了认知并产生了抗抑郁作用，而没有NMDA受体拮抗剂的拟精神病副作用
2. GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects [J] . Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, Neuropsychopharmacology . 2013,第5期

机译：NMDA受体甘氨酸位功能性局部激动剂GLYX-13诱导抗抑郁样作用而没有氯胺酮样副作用
3. GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia Injury In Vivo and Vitro by Differential Modulations of NMDA Receptors Subunit Components at Different Post-Ischemia Stage in Mice [J] . Chen Zheng, Zhi H. Qiao, Meng Z. Hou, Frontiers in Aging Neuroscience . 2017,第2期

机译：NMDA受体甘氨酸位功能性局部激动剂GLYX-13通过在缺血后不同阶段对NMDA受体亚基组分的差异调节来减轻脑缺血性损伤。在老鼠
4. EFFECTS OF NMDA AND NON-NMDA RECEPTORS ANTAGONISTS ON THE BEHAVIOR OF CULTURED CORTICAL NETWORKS [C] . Laura Bonzano, Marco Bove, Sergio Martinoia Brain Inspired Cognitive Systems . 2004

机译：NMDA和非NMDA受体对拮抗剂对培养皮质网络行为的影响
5. Effects of voluntary exercise and NMDA receptor subunit selective antagonists on levodopa-induced motor response complications in hemiparkinsonian rats. [D] . Wessell, Ryan H. 2006

机译：自愿运动和NMDA受体亚基选择性拮抗剂对左帕金森病大鼠左旋多巴诱发的运动反应并发症的影响。
6. GLYX-13 a NMDA Receptor Glycine-Site Functional Partial Agonist Induces Antidepressant-Like Effects Without ketamine-like Side Effects [O] . Jeffrey Burgdorf, Xiao-lei Zhang, Katherine L Nicholson, 2013

机译：NMDA受体甘氨酸位功能性局部激动剂GLYX-13诱导类似抗抑郁药的作用而没有氯胺酮样的副作用
7. GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists [O] . Joseph R Moskal, Ronald Burch, Jeffrey S Burgdorf, 2013

机译：甘草-13，NMDA受体甘氨酸甘氨酸局部激动剂增强了认知，并产生抗抑郁作用，没有NMDA受体拮抗剂的灵活副作用

GLYX-13 an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

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