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A Perspective Review on Numerical Simulations of Hemodynamics in Aortic Dissection

机译:主动脉夹层血流动力学数值模拟的前瞻性回顾

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摘要

Aortic dissection, characterized by separation of the layers of the aortic wall, poses a significant challenge for clinicians. While type A aortic dissection patients are normally managed using surgical treatment, optimal treatment strategy for type B aortic dissection remains controversial and requires further evaluation. Although aortic diameter measured by CT angiography has been clinically used as a guideline to predict dilation in aortic dissection, hemodynamic parameters (e.g., pressure and wall shear stress), geometrical factors, and composition of the aorta wall are known to substantially affect disease progression. Due to the limitations of cardiac imaging modalities, numerical simulations have been widely used for the prediction of disease progression and therapeutic outcomes, by providing detailed insights into the hemodynamics. This paper presents a comprehensive review of the existing numerical models developed to investigate reasons behind tear initiation and progression, as well as the effectiveness of various treatment strategies, particularly the stent graft treatment.
机译:以主动脉壁各层分离为特征的主动脉夹层对临床医生提出了重大挑战。虽然通常使用外科手术治疗A型主动脉夹层,但B型主动脉夹层的最佳治疗策略仍存在争议,需要进一步评估。尽管通过CT血管造影术测量的主动脉直径已被临床用作预测主动脉夹层扩张的指南,但已知血流动力学参数(例如压力和壁切应力),几何因素以及主动脉壁的组成会严重影响疾病的进展。由于心脏成像方式的局限性,通过提供对血液动力学的详细见解,数值模拟已广泛用于预测疾病进展和治疗结果。本文对现有的数值模型进行了全面的回顾,该数值模型用于研究泪液引发和进展的原因,以及各种治疗策略(尤其是支架移植治疗)的有效性。

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