Aerosol Interleukin-2 Induces Natural Killer Cell Proliferation in the Lung and Combination Therapy Improves the Survival of Mice with Osteosarcoma Lung Metastasis

摘要

BackgroundWe have previously shown that aerosol interleukin-2 [IL-2] increased the number of intravenously injected human natural killer [NK] cells in the lungs. In this study we investigated whether this increase was secondary to NK cell proliferation and determined the site of the proliferation.