Gold-Catalyzed Diastereoselective Cycloisomerization of Alkylidene Cyclopropane Bearing 16-Diynes

摘要

An unprecedented gold-catalyzed diastereoselective cycloisomerization of 1,6-diynes bearing an alkylidene cyclopropane moiety has been developed. This methodology enables rapid access to a variety of 1,2-trimethylenenorbornanes, important building blocks in the preparations of abiotic and sesquiterpene core structures.