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Gentiolactone a Secoiridoid Dilactone from Gentiana triflora Inhibits TNF-α iNOS and Cox-2 mRNA Expression and Blocks NF-κB Promoter Activity in Murine Macrophages

机译：秦enti内酯中的类固醇碘代双内酯抑制小鼠巨噬细胞中TNF-αiNOS和Cox-2 mRNA表达并阻断NF-κB启动子活性。

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BackgroundGentian roots have been used as a herbal medicine because of their anti-inflammatory activities. However, the molecular mechanisms of these anti-inflammatory effects remain to be completely explained.

机译：背景植物龙胆根由于其抗炎活性而被用作草药。然而，这些抗炎作用的分子机制仍有待完全解释。

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作者
Hidetoshi Yamada; Sayaka Kikuchi; Tomoki Inui; Hideyuki Takahashi; Ken-ichi Kimura;
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年(卷),期 -1(9),11
年度 -1
页码 e113834
总页数 14
原文格式 PDF
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入库时间 2022-08-21 11:17:10

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专利

1. Eriobotryae Folium Extract Suppresses LPS-Induced iNOS and COX-2 Expression by Inhibition of NF-κB and MAPK Activation in Murine Macrophages [J] . Takuhiro Uto*a Natnaprach Suangkaew*a Osamu Morinaga* Hiroko Kariyazonoy Shigeru Oisoy and Yukihiro Shoyama* The American Journal of Chinese Medicine . 2010,第5期

机译：桑rio叶提取物通过抑制小鼠巨噬细胞中的NF-κB和MAPK活化来抑制LPS诱导的iNOS和COX-2表达。
2. Aqueous Extract of Oldenlandia diffusa Suppresses LPS-Induced iNOS, COX-2 and TNF-α Expression in RAW 264.7 Cells via the NF-κB Activity [J] . Jayasooriya RGPT, Kang Chang-Hee, Choi Yung Hyun, Tropical Journal of Pharmaceutical Research . 2011,第4期

机译：白花蛇舌草水提物通过NF-κB活性抑制LPS诱导的RAW 264.7细胞中iNOS，COX-2和TNF-α表达
3. Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1 [J] . LiuL., LiJ., KunduJ.K., Inflammation research: Official journal of the European Histamine Research Society . 2014,第12期

机译：Piceatannol通过阻断NF-κB和AP-1的激活来抑制佛波酯诱导的HR-1无毛小鼠皮肤中COX-2和iNOS的表达
4. Ginsenoside Rp1 a Ginsenoside Derivative Blocks Promoter Activation of iNOS and COX-2 Genes by Suppression of an IKKβ-mediated NF-кB Pathway in HEK293 Cells [O] . Ting Shen, Jaehwi Lee, Myung Hwan Park, 2011

机译：人参皂甙Rp1人参皂甙衍生物通过抑制IKKβ介导的NF-κB通路在HEK293细胞中阻止iNOS和COX-2基因的启动子激活。
5. Gentiolactone, a secoiridoid dilactone from Gentiana triflora, inhibits TNF-α, iNOS and Cox-2 mRNA expression and blocks NF-κB promoter activity in murine macrophages. [O] . Hidetoshi Yamada, Sayaka Kikuchi, Tomoki Inui, 2014

机译：Gentiolactone，来自龙胆（Gentiana triflora）的secoiridoid二内酯，抑制TNF-α，iNOs和Cox-2 mRNa表达并阻断小鼠巨噬细胞中NF-κB启动子活性。

Gentiolactone a Secoiridoid Dilactone from Gentiana triflora Inhibits TNF-α iNOS and Cox-2 mRNA Expression and Blocks NF-κB Promoter Activity in Murine Macrophages

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