Diversity Oriented Synthesis and IKK inhibition of Aminobenzimidazole Tethered quinazoline-24-diones thioxoquinazolin-4-ones benzodiazepine-235-triones isoxazoles and isoxazolines

摘要

The derivatization of resin-bound aminobenzimidazole toward The parallel solid-phase synthesis of aminobenzimidazole tethered pharmacologically important heterocycles such as quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines is reported. All the compounds were tested for IKK inhibition. Only one compound elicited significant inhibition of IKKε, TBK-1 and IKK2.