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Effect of In-Painting on Cortical Thickness Measurements in Multiple Sclerosis: A Large Cohort Study

机译:彩绘对多发性硬化症皮质厚度测量的影响:一项大型队列研究

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摘要

A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more significant in the left hemisphere compared to the right, was more prominent at 1.5 T relative to 3 T, and was greater at higher lesion volumes. Our results show that even for data acquired at 1.5 T in patients with high lesion load, the mean cortical thickness difference with and without in-painting is ~2%. Based on these results, it appears that in-painting has only a small effect on the estimated regional and global cortical thickness.
机译:对参加III期多中心临床试验的918例复发缓解型多发性硬化患者的大型队列进行了磁共振成像检查,评估了病变修复对皮层厚度的影响。开发并实现了一种自动病变修复算法。使用FreeSurfer管道(带和不带涂料)测量皮质厚度。使用FreeSurfer的配对分析管道评估了涂装效果。还进行了多变量回归分析,其中场强和病变负荷为其他因素。总的来说,估计的皮层厚度与未涂漆时不同。观察到绘画效果取决于区域,左半球比右半球更显着,在1.5 T时相对于3 T时更突出,在病灶体积更大时更佳。我们的结果表明,即使对于高病灶负荷患者在1.5 T时获得的数据,使用和不使用涂料的平均皮层厚度差约为2%。根据这些结果,看来内涂对估计的区域和整体皮层厚度影响很小。

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