Correlation Between Hypoglycemia Glycemic Variability and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes: Analysis of Data from the ITN T1DAL Trial

摘要

PurposeIn natural history studies, maintenance of higher levels of C-peptide secretion (a measure of endogenous insulin production) correlates with a lower incidence of major hypoglycemic events in patients with type 1 diabetes (T1D), but is unclear whether this will also be true for drug-induced C-peptide preservation.