Enantioselective Conjunctive Cross-Coupling of Bis(alkenyl) Borates: A General Synthesis of Chiral Allylboron Reagents

摘要

Palladium catalyzed conjunctive cross-coupling is used for the synthesis of enantioenriched allylboron reagents. This reaction employs non-symmetric bis(alkenyl)borates as substrates and appears to occur by a mechanism that involves selective activation of the less substituted alkene, followed by migration of the more substituted alkene during the course of a Pd-induced metalate rearrangement.