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Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation

机译:用血浆金纳米星标记的人类脂肪干细胞用于细胞跟踪和光热癌细胞消融

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摘要

BackgroundNanoparticles show promise within the field of cancer therapeutics. Among the nanoparticle constructs, gold nanostars (GNSs) are unique nanoplatforms that can be imaged in real-time and transform light energy into heat to ablate cells. However, targeted delivery of GNSs to tumors remains a challenge. Adipose-derived stem cells (ASCs) migrate towards tumor niches in response to chemokines. The ability of ASCs to migrate and integrate into tumors makes them ideal vehicles for the targeted delivery of cancer nanotherapeutics.
机译:背景纳米粒子在癌症治疗领域显示出希望。在纳米颗粒构造中,金纳米星(GNS)是独特的纳米平台,可以实时成像并将光能转化为热量以消融细胞。然而,将GNS靶向递送至肿瘤仍然是挑战。响应于趋化因子,脂肪干细胞(ASC)迁移至肿瘤壁ni。 ASC迁移并整合到肿瘤中的能力使其成为靶向递送癌症纳米治疗剂的理想载体。

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