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Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling Loss of Lens Specific Markers and Changes in Stress Response Proteins

机译：缺乏谷胱甘肽的LEGSKO小鼠晶状体的蛋白质组学分析揭示了EMT信号的激活晶状体特异性标志物的缺失以及应激反应蛋白的变化

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PurposeTo determine global protein expression changes in the lens of the GSH-deficient LEGSKO mouse model of age-related cataract for comparison with recently published gene expression data obtained by RNA-Seq transcriptome analysis.

机译：目的确定年龄相关性白内障的GSH缺陷型LEGSKO小鼠模型的晶状体中的整体蛋白表达变化，以便与最近发表的通过RNA-Seq转录组分析获得的基因表达数据进行比较。

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期刊名称 other
作者
Jeremy A. Whitson; Phillip A. Wilmarth; John Klimek; Vincent M. Monnier; Larry David; Xingjun Fan;
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年(卷),期 -1(113),-1
年度 -1
页码 84–96
总页数 28
原文格式 PDF
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关键词
LEGSKO mouse cataract glutathione oxidative stress NRF2 epithelial-mesenchymal transition isobaric tagging TMT proteomics;

机译：LEGSKO小鼠;白内障;谷胱甘肽;氧化应激;NRF2;上皮-间质转化;同量异位标记;TMT;蛋白质组学;

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1. Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins [J] . Jeremy A. Whitson, Phillip A. Wilmarth, John Klimek, Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2017,第期

机译：谷胱甘肽缺陷腿小鼠小鼠镜片的蛋白质组学分析显示EMT信号传导的激活，镜片特异性标记的损失，以及应力反应蛋白的变化
2. Transcriptome analysis of the cataract-prone GSH-depleted LEGSKO mouse lens reveals adaptations and EMT-like response [J] . Whitson Jeremy, Wei Zongbo, Zhang Xiang, Investigative ophthalmology & visual science . 2017,第8期

机译：对白内障的转录组分析分析，易于GSH耗尽的腿杆鼠标镜头显示适应和EMT样响应
3. Transcriptome analysis of the cataract-prone GSH-depleted LEGSKO mouse lens reveals adaptations and EMT-like response [J] . Whitson Jeremy, Wei Zongbo, Zhang Xiang, Investigative ophthalmology & visual science . 2017,第8期

机译：对白内障的转录组分析分析，易于GSH耗尽的腿杆鼠标镜头显示适应和EMT样响应
4. Targeted Proteomic analysis using parallel reaction monitoring revealed longitudinal change in level of proteins in activation of BV2 mouse microglia [C] . Jongmin Woo, Dohyun Han, Youngsoo Kim ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用平行反应监测的靶向蛋白质组学分析揭示了BV2小鼠小鼠的激活中蛋白质水平的纵向变化
5. Exploring the role of fibroblast growth factor (FGF) signaling in mouse lens fiber differentiation through tissue-specific disruption of FGF receptor gene family [D] . Zhao, Haotian 2004

机译：探索成纤维细胞生长因子（FGF）信号通过FGF受体基因家族的组织特异性破坏在小鼠晶状体纤维分化中的作用
6. Species-specific lens activation of the thymidine kinase promoter by a single copy of the mouse alpha A-CRYBP1 site and loss of tissue specificity by multimerization. [O] . C M Sax, J F Klement, J Piatigorsky 1990

机译：小鼠αA-CRYBP1位点的单个拷贝对胸苷激酶启动子的物种特异性晶状体激活以及通过多聚作用丧失组织特异性。
7. Proteomic analysis of the glutathione-deficient LEGSKO mouse lens reveals activation of EMT signaling, loss of lens specific markers, and changes in stress response proteins [O] . Jeremy A. Whitson, Phillip A. Wilmarth, John Klimek, 2017

机译：谷胱甘肽缺乏腿小鼠镜片的蛋白质组学分析显示EMT信号传导，镜片损失的激活，以及应力反应蛋白的变化
8. Protective Role of PI3-kinase/Akt/eNOS Signaling in Mechanical Stress Through Inhibition of p38 Mitogen-Activated Protein Kinase in Mouse Lung [R] . Peng, X., Damarla, M., Skirball, J., 2010

机译：pI3-激酶/ akt / eNOs信号通过抑制小鼠肺中p38丝裂素活化蛋白激酶对机械应激的保护作用

Proteomic Analysis of the Glutathione-Deficient LEGSKO Mouse Lens Reveals Activation of EMT Signaling Loss of Lens Specific Markers and Changes in Stress Response Proteins

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