Longitudinal association of amyloid-β and anxious-depressive symptoms in cognitively normal older adults

摘要

OBJECTIVEIn order to understand the role of depressive symptoms in preclinical Alzheimer’s disease (AD) it is essential to define their temporal relationship to AD proteinopathies in cognitively normal (CN) older adults. The study objective was to examine associations of brain amyloid-beta (Aβ) and longitudinal measures of depression and depressive-symptom clusters in a CN sample.