Association of CYP3A4/5 ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen

机译：CYP3A4 / 5ABCB1和ABCC2多态性与他莫昔芬治疗的泰国乳腺癌患者的临床结局

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BackgroundPharmacogenetic study of cytochrome P450 (CYP) gene CYP2D6 and tamoxifen outcomes remain controversial. Apart from CYP2D6, other drug-metabolizing enzymes and transporters also play a role in tamoxifen metabolic pathways. The aim of this study is to investigate the impact of CYP3A4/5, ABCB1, and ABCC2 polymorphisms on the risk of recurrence in Thai patients who received tamoxifen adjuvant therapy.

机译：背景技术细胞色素P450（CYP）基因CYP2D6和他莫昔芬转归的药理研究仍然存在争议。除CYP2D6外，其他药物代谢酶和转运蛋白在他莫昔芬的代谢途径中也起作用。这项研究的目的是调查CYP3A4 / 5，ABCB1和ABCC2多态性对接受他莫昔芬辅助治疗的泰国患者复发风险的影响。

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期刊名称 Pharmacogenomics and Personalized Medicine
作者
Insee Sensorn; Ekaphop Sirachainan; Montri Chamnanphon; Ekawat Pasomsub; Narumol Trachu; Porntip Supavilai; Chonlaphat Sukasem; Darawan Pinthong;
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作者单位

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年(卷),期 2013(6),-1
年度 2013
页码 93–98
总页数 6
原文格式 PDF
正文语种
中图分类药学;
关键词
breast cancer CYP3A4/5 drug transporters pharmacogenetics disease-free survival tamoxifen;

机译：乳腺癌;CYP3A4 / 5;药物转运蛋白;药物遗传学;无病生存期;他莫昔芬;

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1. Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen [J] . Insee Sensorn, Ekaphop Sirachainan, Montri Chamnanphon, Pharmacogenomics and Personalized Medicine . 2013,第10期

机译：CYP3A4 / 5，ABCB1和ABCC2基因多态性与他莫昔芬治疗的泰国乳腺癌患者的临床结局
2. ABCB1 and ABCC2 and the risk of distant metastasis in Thai breast cancer patients treated with tamoxifen [J] . Insee Sensorn, Chonlaphat Sukasem, Ekaphop Sirachainan, OncoTargets and therapy . 2016,第4期

机译：他莫昔芬治疗的泰国乳腺癌患者的ABCB1和ABCC2以及远处转移的风险
3. Erratum: Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer [J] . Ji-Youn Han MD PhD Hyeong-Seok Lim MD Yeon-Kyeong Yoo Eun Soon Shin PhD Yong Hoon Park PhD Sung Young Lee Jong-Eun Lee PhD Dea Ho Lee MD Heung Tae Kim MD Jin Soo Lee MD Cancer . 2010,第15期

机译：勘误：ABCB1，ABCC2和ABCG2多态性与伊立替康药代动力学和晚期非小细胞肺癌患者临床结局的关系
4. Clinical Outcome of Breast and Ovarian Cancer Patients Treated after High-Dose Chemotherapy and Autologous Stem Cell Rescue with Theratope (STn-KLH) Cancer Vaccine: Theratope (STn-KLH) Cancer Vaccine following Autologous Transplant [C] . Leona A. Holmberg, Katherine A. Guthrie, Brenda M. Sandmaier Chemical glycobiology . -1

机译：大剂量化学疗法和自体干细胞拯救治疗的Theratope（STn-KLH）癌症疫苗治疗的乳腺癌和卵巢癌患者的临床结果：自体移植后的Theratope（STn-KLH）癌症疫苗
5. Associations between serum vitamin D, genetic polymorphisms in the vitamin D pathway, and sarcopenia with overall and breast cancer-specific mortality in a cohort of breast cancer survivors. [D] . Villasenor, Adriana. 2011

机译：人群中的血清维生素D，维生素D途径的遗传多态性和肌肉减少症与乳腺癌幸存者的总体死亡率和乳腺癌特异性死亡率之间的关联。
6. ABCB1 and ABCC2 and the risk of distant metastasis in Thai breast cancer patients treated with tamoxifen [O] . Insee Sensorn, Chonlaphat Sukasem, Ekaphop Sirachainan, 2016

机译：他莫昔芬治疗的泰国乳腺癌患者的ABCB1和ABCC2以及远处转移的风险
7. Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen [O] . Insee Sensorn, Ekaphop Sirachainan, Montri Chamnanphol, 2013

机译：CYP3A4 / 5，ABCB1和ABCC2多态性和乳腺癌患者的临床结果治疗Tamoxifen

Association of CYP3A4/5 ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen

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