Novel mesostructured silica microparticles are synthesized, characterized and investigated as a drug delivery system (DDS) for antimicrobial applications. The materials exhibit relatively high density (0.56 g per 1 g SiO2) of BAC, pore channels of 18 Å in width, and high surface area (1500 m2/g). Comparison of SAXRD pattern with BJH pore size distribution data suggests that the 18 Å pores exhibit short range ordering and a wall thickness of ca. 12 Å. Drug release studies demonstrate pH-responsive controlled release of BAC without additional surface modification of the materials. Prolonged drug release data was analyzed using a power law (Korsmeyer-Peppas) model and indicates substantial differences in release mechanism in acidic (pH 4.0, 5.0, 6.5) versus neutral (pH 7.4) solutions. Microbiological assays demonstrate a significant time-dependent reduction in Staphylococcus aureus and Salmonella enterica viability above 10 and 130 mg L−1 of the synthesized materials, respectively. The viability of cells is reduced over time compared to control samples. The findings will help in widening the use of BAC as a disinfectant and bactericidal agent, especially in pharmaceutical and food industries where Gram-positive and Gram-negative bacterial contamination is common.
展开▼
机译:合成,表征和研究了新颖的介孔结构二氧化硅微粒,作为用于抗菌应用的药物递送系统(DDS)。该材料具有相对较高的BAC密度(每1 g SiO2为0.56 g),宽度为18Å的孔道和较高的表面积(1500 m 2 sup> / g)。 SAXRD图样与BJH孔径分布数据的比较表明,18Å孔表现出短程有序性,壁厚约为。 12Å。药物释放研究表明,pH响应性BAC控释无需对材料进行额外的表面修饰。使用幂律(Korsmeyer-Peppas)模型分析了延长的药物释放数据,结果表明酸性(pH 4.0、5.0、6.5)与中性(pH 7.4)溶液的释放机理存在实质性差异。微生物分析表明,分别高于10和130 mg L -1 sup>的合成材料时,金黄色葡萄球菌和肠炎沙门氏菌的活力分别显着降低。与对照样品相比,细胞的活力随着时间的推移而降低。这些发现将有助于扩大BAC作为消毒剂和杀菌剂的应用,特别是在革兰氏阳性和革兰氏阴性细菌污染普遍的制药和食品行业。
展开▼