Warfarin as a therapeutic option in the control of chronic cluster headache: a report of threecases

摘要

Chronic cluster headache remains refractory to medical therapy in at least 30% of those who suffer from this condition. The lack of alternative medical therapies that are as effective as, or more effective than, lithium carbonate makes new therapies necessary for this highly disabling condition. Based on a previous report, we gave oral anticoagulants to three patients with chronic cluster headache. Two of them remained cluster headachefree while taking warfarin. In the third patient, the use of warfarin for three weeks initially increased the frequency and intensity of clusterheadache attacks but subsequentlyinduced a prolonged remission. Inspite of the paucity of data available,oral anticoagulation appears tobe a promising therapy for chroniccluster headache.