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Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells

机译：车前草内酯抑制大肠癌细胞转化生长因子β1诱导的上皮-间质转化

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摘要

Background/AimsTransforming growth factor-β1 (TGF-β1) induction of epithelial-mesenchymal transition (EMT) is one of the mechanisms by which colorectal cancer (CRC) cells acquire migratory and invasive capacities, and subsequently metastasize. Parthenolide (PT) expresses multiple anti-cancer and anti-inflammatory activities that inhibit nuclear factor κB by targeting the IκB kinase complex. In the present study, we aimed to investigate whether PT can inhibit TGF-β1-induced EMT in CRC cell lines.

机译：背景/目的转化生长因子-β1（TGF-β1）诱导的上皮-间质转化（EMT）是结直肠癌（CRC）细胞获得迁徙和侵袭能力并随后转移的机制之一。 Parthenolide（PT）通过靶向IκB激酶复合物表达多种抑制核因子κB的抗癌和抗炎活性。在本研究中，我们旨在研究PT是否可以抑制CRC细胞系中TGF-β1诱导的EMT。

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期刊名称 Intestinal Research
作者
Shi Mao Zhu; Yong Ran Park; Seung Yong Seo; In Hee Kim; Soo Teik Lee; Sang Wook Kim;
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作者单位

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年(卷),期 2019(17),4
年度 2019
页码 527–536
总页数 10
原文格式 PDF
正文语种
中图分类外科学;
关键词
Transforming growth factor beta 1 Epithelial-mesenchymal transition Parthenolide Colorectal neoplasms;

机译：转化生长因子β1;上皮-间充质转化;单性白菊内酯;结直肠肿瘤;

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专利

1. Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells [J] . Shi Mao Zhu, Yong Ran Park, Seung Yong Seo, Intestinal research. . 2019,第4期

机译：车前草内酯抑制大肠癌细胞转化生长因子β1诱导的上皮-间质转化
2. Transcription factor glioma-associated oncogene homolog 1 is required for transforming growth factor-beta 1-induced epithelial-mesenchymal transition of non-small cell lung cancer cells [J] . Li Hua, Da Li-Jun, Fan Wei-Dong, Molecular medicine reports . 2015,第5期

机译：转录因子胶质瘤相关癌基因同源物1是转化生长因子-β1诱导的非小细胞肺癌细胞上皮-间质转化的必需条件
3. Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro [J] . Juan He, Ya-Li Jiang, Yan Wang, 中华医学杂志（英文版） . 2020,第007期

机译：过度表达miR-34a的间充质干细胞的微泡在体外抑制转化生长因子-β1诱导的肾小管上皮细胞上皮-间质转化
4. Alg-g-PEG nanosphere-mediated intracellular growth factor delivery inhibits cancer cell proliferation [C] . Tianxin Miao, Spencer L Fenn, Jeffrey L Spees, World biomaterials congress . 2016

机译：Alg-g-PEG纳米球介导的细胞内生长因子传递抑制癌细胞增殖
5. Repressive role of stabilized hypoxia inducible factor 1α expression on transforming growth factor β‐induced extracellular matrix production in lung cancer cells [D] . Ando Akira, 安藤啓 2019

机译：稳定的缺氧诱导因子1α表达对肺癌细胞转化生长因子β诱导的细胞外基质产生的抑制作用
6. Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro [O] . Juan He, Ya-Li Jiang, Yan Wang, 2020

机译：过度表达miR-34a的间充质干细胞的微泡在体外抑制转化生长因子-β1诱导的肾小管上皮细胞上皮-间质转化
7. Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells [O] . Shi Mao Zhu, Yong Ran Park, Seung Yong Seo, 2019

机译：嘌呤醇素抑制在结肠直肠癌细胞中转化生长因子β1诱导的上皮间过渡

Parthenolide inhibits transforming growth factor β1-induced epithelial-mesenchymal transition in colorectal cancer cells

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