Modulation of the perforant path-evoked potential in dentate gyrus as a function of intrahippocampal β-adrenoceptor agonist concentration in urethane-anesthetized rat

摘要

Backgroundβ-adrenoceptor activation in the hippocampus is sufficient to induce heterosynaptic long-term potentiation of perforant path input to the dentate gyrus. However, in vitro and in vivo studies suggest the plasticity effects of β-adrenoceptor activation may vary depending on the level of receptor activation.