O4.6. GENOME-WIDE ASSOCIATION STUDY HERITABILITY ESTIMATION AND POLYGENIC RISK ANALYSIS OF SUSCEPTIBILITY TO INFECTIONS IN 65534 INDIVIDUALS WITH SEVERE MENTAL DISORDERS AND POPULATION CONTROLS

摘要

BackgroundInfections are one of the major disease burdens internationally; however, the genetic architecture of infections is largely unknown. The human leukocyte antigen (HLA) loci have been implicated in susceptibility for infections; however, to date, largescale HLA type and genome wide association studies (GWAS) of infections have been lacking. We aim to investigate the genetic architecture of infections with GWAS of single-nucleotide polymorphisms (SNPs) and HLA types, including associations with mental disorders.