Hand, foot, and mouth disease (HFMD) is a common childhood infection that causes a substantial disease burden in the Asia-Pacific region. Various climate variables, such as humidity and temperature, have been associated with HFMD. However, few studies have assessed the impact of PM10 on childhood HFMD. This study investigated the association between PM10 and HFMD. We fitted a standard distributed lag non-linear model to investigate the temporal lagged relationship between PM10 and HFMD, and then further assessed whether this relationship varied by gender and pathogen. Between 2011 and 2015, a total of 122,564 HFMD cases under 15 years of age were reported in Chengdu. The PM10-HFMD associations were shown to be non-linear in all subgroups, with the peak at 101–218 μg/m3. Male children were more sensitive to PM10 effects. For pathogen-specific relative risks, we found that the risk estimates were generally higher in cases of CVA16 infection. Our study provides evidence that PM10 increases the risk of HFMD. Authorities and parents should be fully aware of the impact of PM10 on childhood HFMD. Furthermore, appropriate protective measures should be taken to reduce risks.
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机译:手足口病(HFMD)是一种常见的儿童期感染,在亚太地区造成大量疾病负担。 HFMD与各种气候变量(例如湿度和温度)有关。但是,很少有研究评估PM10对儿童手足口病的影响。这项研究调查了PM10与HFMD之间的关联。我们采用标准的分布滞后非线性模型来研究PM10和HFMD之间的时间滞后关系,然后进一步评估这种关系是否随性别和病原体而变化。在2011年至2015年期间,成都共报告了122564例15岁以下的手足口病病例。在所有亚组中,PM10-HFMD的关联均呈非线性关系,其峰值在101-218μg/ m 3 sup>。男性儿童对PM10的影响更为敏感。对于病原体特异性相对风险,我们发现在CVA16感染的情况下,风险估计通常更高。我们的研究提供证据表明PM10会增加手足口病的风险。当局和父母应充分意识到PM10对儿童手足口病的影响。此外,应采取适当的保护措施以降低风险。
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