首页> 美国卫生研究院文献>Vector Borne and Zoonotic Diseases >Anti-Wolbachia Surface Protein Antibodies Are Present in the Urine of Dogs Naturally Infected with Dirofilaria immitis with Circulating Microfilariae But Not in Dogs with Occult Infections
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Anti-Wolbachia Surface Protein Antibodies Are Present in the Urine of Dogs Naturally Infected with Dirofilaria immitis with Circulating Microfilariae But Not in Dogs with Occult Infections

机译:抗沃尔巴氏菌表面蛋白抗体存在于自然感染双丝虫病伴循环微丝aria病的狗的尿液中但不存在于隐性感染的狗中

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摘要

Heartworm infection (Dirofilaria immitis) can cause kidney damage due to the presence of circulating microfilariae (mf) that contribute to the production and deposit of immune complexes. It has been shown that mf are a major source of Wolbachia antigen during active infection. Here the authors compared urine samples from 19 naturally infected dogs with (mf+) and 12 without (mf−) microfilariae for the presence of proteinuria and anti-Wolbachia Surface Protein (-WSP) IgG in ELISA. Kidneys from 6 mf+ and 3 mf− dogs were also examined by anti-WSP immuno-histochemistry. All infected dogs showed proteinuria, but mf+ dogs had significantly higher values compared to mf−dogs. Mf+ dogs had optical density values for anti-WSP IgG consistently higher than established cut-off values and were significantly higher than values for mf− dogs. Kidneys from mf+ dogs showed Wolbachia+ mf in glomerular capillaries. Results strongly suggest that Wolbachia associated with circulating mf may contribute to immune-mediated kidney disease in dogs with heartworm infection.
机译:由于存在循环微丝虫(mf),导致丝虫免疫复合物的产生和沉积,丝虫感染(Dirofilaria炎)可引起肾脏损害。已经表明,mf是主动感染期间Wolbachia抗原的主要来源。在这里,作者们比较了ELISA中存在蛋白尿症和抗Wolbachia表面蛋白(-WSP)IgG的存在,对来自19只自然感染狗的尿液样本(mf +)和12个没有(mf-)微丝aria的尿液样本进行了比较。还通过抗WSP免疫组织化学检查了6 mf +和3 mf-狗的肾脏。所有感染的狗均显示蛋白尿,但mf +狗的值明显高于mf-狗。 Mf +狗的抗WSP IgG的光密度值始终高于既定的临界值,并且显着高于mf-狗的值。来自MF +狗的肾脏在肾小球毛细血管中显示出Wolbachia + MF。结果强烈表明,与循环性mf相关的Wolbachia可能导致患有丝虫感染的狗的免疫介导的肾脏疾病。

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