Special Issue on Genetics and Aging: Cancer and Longevity—Is There a Trade-off? A Study of Cooccurrence in Danish Twin Pairs Born 1900–1918

摘要

Background.Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, vice versa, that longevity potential comes with the cost of increased cancer risk. This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin.