Research and applications: Extracting coordinated patterns of DNA methylation and gene expression in ovarian cancer

摘要

ObjectiveDNA methylation, a regulator of gene expression, plays an important role in diverse biological processes including developmental process, carcinogenesis and aging. In particular, aberrant DNA methylation has been largely observed in several types of cancers. Currently, it is important to extract disease-specific gene sets associated with the regulation of DNA methylation.