Differential regional expression patterns of α-synuclein TNF-α and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment

摘要

BackgroundParaquat (1, 1-dimethyl-4, 4-bipyridium dichloride; PQ) causes neurotoxicity, especially dopaminergic neurotoxicity, and is a supposed risk factor for Parkinson's disease (PD). However, the cellular and molecular mechanisms of PQ-induced neurodegeneration are far from clear. Previous studies have shown that PQ induces neuroinflammation and dopaminergic cell loss, but the prime cause of those events is still in debate.