Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

摘要

BackgroundNeuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused memory impairments. In the present study, we investigated the possible preventive effects of 4-O-methylhonokiol, a constituent of Magnolia officinalis, on memory deficiency caused by LPS, along with the underlying mechanisms.