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Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output

机译：使用舒张压和收缩压钳模仿完整的心肌细胞的心动周期；测量功率输出

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摘要

AimsA single isolated cardiomyocyte is the smallest functional unit of the heart. Yet, all single isolated cardiomyocyte experiments have been limited by the lack of proper methods that could reproduce a physiological cardiac cycle. We aimed to investigate the contractile properties of a single cardiomyocyte that correctly mimic the cardiac cycle.

机译：目的单个孤立的心肌细胞是心脏的最小功能单元。然而，所有单个孤立的心肌细胞实验都因缺乏能够复制生理性心动周期的适当方法而受到限制。我们旨在研究正确模拟心脏周期的单个心肌细胞的收缩特性。

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期刊名称 Cardiovascular Research
作者
Michiel Helmes; Aref Najafi; Bradley M. Palmer; Ernst Breel; Niek Rijnveld; Davide Iannuzzi; Jolanda van der Velden;
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作者单位

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年(卷),期 -1(111),1
年度 -1
页码 66–73
总页数 8
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Cardiomyocyte function Microtechnology Force–length relation;

机译：心肌细胞功能;微技术;力长关系;

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专利

1. Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output [J] . Helmes Michiel, Najafi Aref, Palmer Bradley M., Cardiovascular Research . 2016,第1期

机译：使用舒张压和收缩压钳模仿完整的心肌细胞的心动周期;测量功率输出
2. Single adult rabbit and rat cardiac myocytes retain the Ca2+- and species-dependent systolic and diastolic contractile properties of intact muscle. [J] . M C Capogrossi, A A Kort, H A Spurgeon, The Journal of general physiology . 1986,第5期

机译：单个成年兔和大鼠心肌细胞保留完整肌肉的Ca2 +和物种依赖性的收缩和舒张收缩特性。
3. Biological markers of cardiac damage are not related to measures of cardiac systolic and diastolic function using cardiovascular magnetic resonance and echocardiography after an acute bout of prolonged endurance exercise. [J] . Wilson M, OHanlon R, Prasad S, British journal of sports medicine . 2011,第10期

机译：在长时间耐力运动的急性发作后，使用心血管磁共振和超声心动图检查对心脏损害的生物学指标与心脏收缩和舒张功能的测量无关。
4. Analysis of cardiac micro-acceleration signals for the estimation of systolic and diastolic time intervals in cardiac resynchronization therapy [C] . Giorgis L., Hernandez A.I., Amblard A., Computers in Cardiology, 2008 . 2008

机译：分析心脏微加速度信号以估计心脏再同步治疗中的收缩和舒张时间间隔
5. Cardiac power output, its role in defining heart failure for future mechanical circulatory support. [D] . Garcia, Jorge. 2011

机译：心脏功率输出，其在定义心力衰竭中的作用，为将来的机械循环支持。
6. Single adult rabbit and rat cardiac myocytes retain the Ca2+- and species-dependent systolic and diastolic contractile properties of intact muscle [O] . 1986

机译：单个成年兔和大鼠心肌细胞保留完整肌肉的Ca2 +和物种依赖性的收缩和舒张收缩特性
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Mimicking the cardiac cycle in intact cardiomyocytes using diastolic and systolic force clamps; measuring power output

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