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A randomized double-blind placebo-controlled phase II study of maintenance therapy with tasquinimod in patients with metastatic castration-resistant prostate cancer responsive to or stabilized during first-line docetaxel chemotherapy

机译：对多西他赛一线化疗有反应或稳定的转移性去势抵抗性前列腺癌患者使用tasquinimod维持治疗的随机双盲安慰剂对照II期研究

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摘要

BackgroundThis phase II study was conducted to assess clinical efficacy of tasquinimod maintenance therapy in patients with metastatic castrate-resistant prostate cancer not progressing during first-line docetaxel-based therapy.

机译：背景这项II期研究旨在评估他克莫德维持治疗对转移性去势抵抗性前列腺癌患者在一线多西他赛为基础的治疗中未进展的临床疗效。

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期刊名称 Annals of Oncology
作者
K Fizazi; A Ulys; L Sengeløv; M Moe; S Ladoire; A Thiery-Vuillemin; A Flechon; A Guida; J Bellmunt; M A Climent; S Chowdhury; H Dumez; M Matouskova; N Penel; S Liutkauskiene; L Stachurski; C N Sternberg; F Baton; N Germann; G Daugaard;
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作者单位

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年(卷),期 -1(28),11
年度 -1
页码 2741–2746
总页数 6
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
tasquinimod prostate cancer castrate-resistant maintenance therapy docetaxel;

机译：他克莫德;前列腺癌;去势抵抗;维持疗法;多西他赛;

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专利

1. A randomized, double-blind, placebo-controlled phase II study of maintenance therapy with tasquinimod in patients with metastatic castration-resistant prostate cancer responsive to or stabilized during first-line docetaxel chemotherapy [J] . Fizazi K., Ulys A., Sengelov L., Annals of oncology: official journal of the European Society for Medical Oncology . 2017,第11期

机译：随机，双盲，安慰剂对照期II研究患者维持治疗患者维持治疗患者转移阉割抗阉割前列腺癌的患者敏感或稳定在一线多西紫杉醇化疗期间
2. A randomized, double-blind, placebo-controlled, Phase II study with and without enzastaurin in combination with docetaxel-based chemotherapy in patients with castration-resistant metastatic prostate cancer [J] . DreicerR., GarciaJ., RiniB., Investigational new drugs. . 2013,第4期

机译：一项针对有去势抵抗性转移性前列腺癌的患者进行的，有或没有enzastaurin联合基于多西他赛的化疗的随机，双盲，安慰剂对照II期研究
3. Randomized, Double-Blind, Placebo-Controlled Phase III Study of Tasquinimod in Men With Metastatic Castration-Resistant Prostate Cancer [J] . Sternberg Cora, Armstrong Andrew, Pili Roberto, Journal of Clinical Oncology . 2016,第22期

机译：Tasquinimod在转移性去势抵抗性前列腺癌男性中的随机，双盲，安慰剂对照III期研究
4. Is High-Dose Chemotherapy Plus Stem-Cell Transplant the Standard Treatment for Patients Failing First-Line Chemotherapy for Metastatic Germ Cell Tumor? [C] . Christian Kollmannsberger, Lawrence Einhorn, Craig Nichols Genitourinary Cancers Symposium. . 2014

机译：高剂量化疗加干细胞移植对转移细胞肿瘤的一线化疗失败的患者的标准治疗吗？
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. Randomized Double-Blind Placebo-Controlled Phase III Trial Comparing Docetaxel and Prednisone With or Without Bevacizumab in Men With Metastatic Castration-Resistant Prostate Cancer: CALGB 90401 [O] . William Kevin Kelly, Susan Halabi, Michael Carducci, -1

机译：转移性去势抵抗性前列腺癌男性患者中多西他赛和泼尼松联合或不联合贝伐单抗的随机双盲安慰剂对照Ⅲ期临床试验：CALGB 90401
7. A randomized, double-blind, placebo-controlled phase II study of maintenance therapy with tasquinimod in patients with metastatic castration-resistant prostate cancer responsive to or stabilized during first-line docetaxel chemotherapy [O] . K. Fizazi, A. Ulys, L. Sengeløv, 2017

机译：随机，双盲，安慰剂对照期II研究患者维持治疗患者维持治疗患者转移性阉割抗阉割前列腺癌患者响应或稳定在一线多西紫杉醇化疗期间

A randomized double-blind placebo-controlled phase II study of maintenance therapy with tasquinimod in patients with metastatic castration-resistant prostate cancer responsive to or stabilized during first-line docetaxel chemotherapy

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