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Randomized clinical trial testing the efficacy and safety of 0.5 colchicine cream versus photodynamic therapy with methyl aminolevulinate in the treatment of skin field cancerization: study protocol

机译：随机临床试验测试0.5％秋水仙碱乳膏与氨基乙酰丙酸甲酯光动力疗法在治疗皮肤癌中的功效和安全性：研究方案

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BackgroundThe primary clinical manifestation of skin field cancerization is the presence of actinic keratoses (AKs). Current treatments for AKs related to skin field cancerization include photodynamic therapy (PDT) and colchicine. The objective of this study is to evaluate the efficacy and safety of 0.5% colchicine cream versus PDT with methyl aminolevulinate (MAL-PDT) in the treatment of skin field cancerization.

机译：背景技术皮肤癌的主要临床表现是光化性角化病（AKs）的存在。与皮肤癌相关的AK的当前治疗方法包括光动力疗法（PDT）和秋水仙碱。这项研究的目的是评估0.5％秋水仙碱乳膏相对于PDT与氨基乙酰丙酸甲酯（MAL-PDT）的疗效和安全性。

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期刊名称 BMC Cancer
作者
Anna Carolina Miola; Eliane Roio Ferreira; Luciana Patricia Fernandes Abbade; Juliano Vilaverde Schmitt; Helio Amante Miot;
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作者单位

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年(卷),期 2018(18),-1
年度 2018
页码 340
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
Actinic keratoses Colchicine Methyl aminolevulinate Skin cancer Skin field cancerization Photodynamic therapy;

机译：光化性角化病;秋水仙碱;氨基乙酰丙酸甲酯;皮肤癌;皮肤癌;光动力疗法;

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1. Randomized clinical trial testing the efficacy and safety of 0.5% colchicine cream versus photodynamic therapy with methyl aminolevulinate in the treatment of skin field cancerization: study protocol [J] . Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, BMC Cancer . 2018,第1期

机译：随机临床试验测试0.5％秋水仙碱霜与光动力学疗法联合氨基乙酰丙酸甲酯在治疗皮肤癌中的功效和安全性：研究方案
2. Effectiveness and safety of 0·5% colchicine cream vs. photodynamic therapy with methyl aminolaevulinate in the treatment of actinic keratosis and skin field cancerization of the forearms: a randomized controlled trial [J] . Miola A.C., Ferreira E.R., Lima T.R.R., British Journal of Dermatology . 2018,第5期

机译：0·5％Colchicine乳膏与甲基氨基乙酰丙酸酯的疗效和安全性在治疗前臂的静脉曲张化和皮肤场癌症中的光动力学治疗：随机对照试验
3. Daylight photodynamic therapy with methyl aminolevulinate cream as a convenient, similarly effective, nearly painless alternative to conventional photodynamic therapy in actinic keratosis treatment: A randomized controlled trial [J] . RubelD.M., SpelmanL., MurrellD.F., British Journal of Dermatology . 2014,第5期

机译：日光光动力疗法使用氨基乙酰丙酸甲酯乳膏作为光化性角化病治疗中常规光动力疗法的一种方便，相似，几乎无痛的替代方法：一项随机对照试验
4. Combination photodynamic therapy using 5-fluorouracil and aminolevulinate enhances tumor-selective production of protoporphyrin Ⅸ and improves treatment efficacy of squamous skin cancers and precancers [C] . Edward V. Maytin, Sanjay Anand Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXV . 2016

机译：5-氟尿嘧啶和氨基乙酰丙酸盐的联合光动力疗法可增强原卟啉of的肿瘤选择性产生，并改善鳞状皮肤癌和癌前病变的治疗效果
5. Efficacy of the Chinese herbal formula CUF2 in the treatment of childhood asthma: Animal experiment, in vitro study and randomized, double-blinded, placebo-controlled clinical trial. [D] . Wong, Yeuk Oi. 2006

机译：中药配方CUF2在治疗儿童哮喘中的功效：动物实验，体外研究以及随机，双盲，安慰剂对照的临床试验。
6. Pooled results of two randomized clinical trials comparing the efficacy and safety of travoprost 0.004/timolol 0.5 in fixed combination versus concomitant travoprost 0.004 and timolol 0.5 [O] . Ronald L Gross, E Kenneth Sullivan, David T Wells, 2007

机译：两项随机临床试验的汇总结果比较了固定组合中travoprost 0.004％/替莫洛尔0.5％与伴有travoprost 0.004％和噻吗洛尔0.5％的疗效和安全性
7. Evaluation of efficacy, safety, and tolerability of fixed dose combination (FDC) of halometasone 0.05% and fusidic acid 2% w/w topical cream versus FDC of betamethasone valerate 0.12% and neomycin sulphate 0.5% w/w topical cream in the treatment of infected eczematous dermatosis in Indian subjects: A randomized open-label comparative phase III multi-centric trial [O] . Dasiga Venkata Subrahmanya Pratap, Mariam Philip, Narayana T Rao, 2013

机译：评价0.05％卤米松和2％华沙酸2％w / w局部乳膏的固定剂量组合（FDC）与戊酸倍他米松0.12％和硫酸新霉素0.5％w / w局部乳膏的FDC治疗中的疗效，安全性和耐受性印度受试者感染的湿疹性皮肤病：一项随机开放标签比较III期多中心试验

Randomized clinical trial testing the efficacy and safety of 0.5 colchicine cream versus photodynamic therapy with methyl aminolevulinate in the treatment of skin field cancerization: study protocol

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