An acute febrile illness associated with unloading silos occurs more frequently than any other farm associated respiratory illness in mid state New York. This report describes 29 cases of organic dust toxic syndrome (also known as pulmonary mycotoxicosis) occurring in 24 men and one woman with a mean age of 29 years. In 16 instances more than one worker was exposed to the dust, and in 12 of these shared exposures more than one worker became ill. Patients presented 5.3 (SD 3.3) hours after inhalation of organic dust and mould with fever (79%), myalgia (76%), chest tightness (72%), cough (66%), and headache (59%). The mean temperature was 38.7 degrees C and the mean white blood cell count 13.2 X 10(9)/l. In contrast to patients with allergic alveolitis, nearly all these patients had normal breath sounds, chest radiographs, and arterial oxygen saturation. Tests for precipitating antibodies to farmer's lung disease antigens gave negative results in all 26 episodes in which they were done; of these, 10 had no evidence of precipitating antibodies to an aqueous extract of the silage associated with their own illness. Organic dust toxic syndrome appears to be a common and substantial respiratory hazard to young farm workers. Despite being frequently mis-diagnosed as farmer's lung, organic dust toxic syndrome is clearly a distinctly different disease process.
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机译：与卸载筒仓相关的急性发热性疾病的发生频率比纽约州中部任何其他农场相关的呼吸系统疾病更为频繁。该报告描述了29例有机尘埃中毒综合症（也称为肺部霉菌中毒），其中24例男性和1例女性的平均年龄为29岁。在16个实例中，有一名以上工人暴露在灰尘下，在这些共有的12种暴露中，有一名以上工人患病。吸入有机粉尘和发霉发烧（79％），肌痛（76％），胸闷（72％），咳嗽（66％）和头痛（59％）后，患者出现5.3（标准差3.3）小时。平均温度为38.7摄氏度，平均白细胞计数为13.2 X 10（9）/ l。与过敏性肺泡炎患者相比，几乎所有这些患者的呼吸音，胸片和动脉血氧饱和度均正常。对农民肺部疾病抗原的沉淀抗体测试在完成的所有26次事件中均显示阴性结果。其中有10个没有证据表明与自身疾病相关的青贮饲料水提取物会沉淀出抗体。有机粉尘中毒综合症对年轻的农场工人似乎是常见的实质性呼吸道危害。尽管经常被误诊为农民的肺部疾病，但有机尘埃中毒综合症显然是截然不同的疾病过程。
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