Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in 18FFDG-PET (PETMETPAT)

摘要

IntroductionThe implementation of spatial-covariance [¹⁸F]fluorodeoxyglucose positron emission tomography–based disease-related metabolic brain patterns as biomarkers has been hampered by intercenter imaging differences. Within the scope of the JPND-PETMETPAT working group, we illustrate the impact of these differences on Parkinson's disease–related pattern (PDRP) expression scores.