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Teratomas in infancy and childhood. A 54-year experience at the Childrens Hospital Medical Center.

机译:畸胎瘤在婴儿期和童年时期。在儿童医院医疗中心拥有54年的经验。

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摘要

The clinical and pathologic features of 254 teratomas from 245 patients are reviewed. All patients were 21 years of age or younger and were treated at the Children's Hospital Medical Center from 1928 to 1982. Tumors arose in the following anatomic sites: sacrococcygeal (102), ovary (94), head and neck (14), retroperitoneum (12), mediastinum (11), testes (eight), central nervous system (nine), liver (two), abdominal wall, and back (one each). One hundred twenty-four tumors (49%) were detected in the newborn period. Teratomas characteristically contained elements derived from all three embryonic germ layers. Tumors with any recognizable component of embryonal carcinoma or other malignant germ cell elements at the time of initial surgery were excluded. Immature teratomas were significantly larger than mature tumors in nearly all sites where statistical analysis was possible. The single most important factor affecting prognosis was whether the tumor could be resected successfully at initial surgery. No patient who did not undergo surgery, or in whom only partial resection was possible, survived the disease--regardless of other treatments used. Based upon the experience reported here the authors conclude: 1) complete surgical resection is the treatment of choice for all childhood teratomas; and 2) this is one of the few childhood tumors where decisions regarding adjuvant therapy must be individualized, particularly with regard to site of origin and age of the patient.
机译:回顾了245例患者中254例畸胎瘤的临床和病理特征。所有患者年龄均在21岁以下,并于1928年至1982年在儿童医院医疗中心接受了治疗。在以下解剖部位出现了肿瘤:sa尾骨(102),卵巢(94),头和颈(14),腹膜后( 12),纵隔(11),睾丸(八),中枢神经系统(九),肝(两),腹壁和背部(各一)。在新生儿期检测到一百二十四个肿瘤(49%)。畸胎瘤特征性地包含来自所有三个胚芽层的元素。排除在初次手术时具有任何可识别的胚胎癌成分或其他恶性生殖细胞成分的肿瘤。在几乎所有可能进行统计分析的部位,未成熟的畸胎瘤均明显大于成熟肿瘤。影响预后的最重要因素是在初次手术时是否可以成功切除肿瘤。不管使用哪种其他治疗方法,没有进行手术或只能部分切除的患者都没有幸存下来。基于此处报道的经验,作者得出以下结论:1)完全手术切除是所有儿童畸胎瘤的首选治疗方法; 2)这是少数儿童肿瘤中的一种,必须对辅助治疗做出个性化的决定,尤其是在患者的起源地和年龄方面。

著录项

  • 期刊名称 Annals of Surgery
  • 作者

    D Tapper; E E Lack;

  • 作者单位
  • 年(卷),期 1983(198),3
  • 年度 1983
  • 页码 398–410
  • 总页数 12
  • 原文格式 PDF
  • 正文语种
  • 中图分类 外科学;
  • 关键词

  • 入库时间 2022-08-17 16:11:04

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