首页> 美国卫生研究院文献>Avicenna Journal of Medical Biotechnology >Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus Obesity and Biochemical Profiles of Serum in Iranian Population
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Investigation of the Association between 5-Hydroxytryptamine Transporter Gene-Linked Polymorphic Region with Type 2 Diabetes Mellitus Obesity and Biochemical Profiles of Serum in Iranian Population

机译:5-羟色胺转运蛋白基因相关的多态性区域与2型糖尿病肥胖症和伊朗人群血清生化特征之间的关系研究

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摘要

Background:Type 2 Diabetes Mellitus (T2DM) is a serious problem in the world. 5-Hydroxytryptamine (5-HT, serotonin) plays an important role in obesity, glucose control and insulin resistance. The polymorphism of the serotonin transporter gene linked promoter region (5-HTTLPR) might influence 5-HTT expression and serotonin uptake. The polymorphism results in two alleles of L (Long) and S (Short). The aim of the present study was to evaluate the association between 5-HTTLPR genotypes in type 2 diabetes mellitus (T2DM), obesity as well as serum biochemical profiles in Iranian population from 2012 until 2015.
机译:背景:2型糖尿病(T2DM)是世界上的一个严重问题。 5-羟色胺(5-HT,5-羟色胺)在肥胖,血糖控制和胰岛素抵抗中起重要作用。血清素转运蛋白基因连接的启动子区域(5-HTTLPR)的多态性可能会影响5-HTT表达和血清素的摄取。多态性导致L(长)和S(短)的两个等位基因。本研究的目的是评估2012年至2015年伊朗人群2型糖尿病(T2DM)中5-HTTLPR基因型与肥胖以及血清生化特征之间的关系。

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