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Turning severe into moderate haemophilia by prophylaxis: are we reaching our goal?

机译：通过预防将重度血友病转变为中度血友病：我们达到目标了吗？

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摘要

BackgroundSince the introduction of prophylaxis, physicians have tried to convert the clinical phenotype of severe haemophilia (SH) into that of moderate haemophilia (MH), but the outcome of patients with SH has never been compared to that of patients with MH.

机译：背景技术自从采取预防措施以来，医生已尝试将重度血友病（SH）的临床表型转换为中度血友病（MH）的表型，但从未将SH患者的结果与MH患者的结果进行比较。

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期刊名称 Blood Transfusion
作者
Ingrid den Uijl; Douwe Biesma; Diederick Grobbee; Kathelijn Fischer;
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作者单位

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年(卷),期 2013(11),3
年度 2013
页码 364–369
总页数 6
原文格式 PDF
正文语种
中图分类血液学检验;
关键词
moderate haemophilia severe haemophilia comparison joint bleeding HJHS;

机译：中度血友病;重度血友病;比较;关节出血;HJHS;

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专利

1. Improvement in health-related quality of life with recombinant factor IX prophylaxis in severe or moderately severe haemophilia B patients: results from the BAX326 Pivotal Study. [J] . J Windyga, V W Lin, J D Epstein, Haemophilia: the official journal of the World Federation of Hemophilia . 2014,第3期

机译：重度或中度重度B型血友病患者使用重组因子IX预防健康相关生活质量的改善：BAX326关键研究的结果。
2. Measuring the impact of changing from standard half‐life (SHL) to extended half‐life (EHL) FVIII prophylaxis on health‐related quality of life (HRQoL) in boys with moderate/severe haemophilia A: Lessons learned with the CHO‐KLAT tool [J] . Carcao Manuel, Zunino Laura, Young Nancy L., Haemophilia: the official journal of the World Federation of Hemophilia . 2020,第1期

机译：测量从标准半衰期（SHL）改变的影响延长半衰期（EHL）FVIII预防对具有中等/严重血耳的男孩健康相关的生活质量（HRQOL）A：与Cho-Klat工具的经验教训
3. Bayesian pharmacokinetic-guided prophylaxis with recombinant factor VIII in severe or moderate haemophilia A [J] . Megias-Vericat J. E., Bonanad S., Haya S., Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2019,第期

机译：贝叶斯药代动力学引导的预防，具有重组因子VIII严重或中度血耳A
4. A Comparison Between Reaching Distance and Work Area for Measuring the Impact of Flexion Synergy on Reaching Function in Chronic Moderate to Severe Hemiparetic Stroke [C] . Michael D. Ellis, Sabeen Admani IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics . 2020

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5. Extending the self-regulatory model linking high goals and unethical behavior: The moderating effects of goal commitment and subconscious priming. [D] . Welsh, David T. 2014

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6. Health-related quality of life of moderate and severe haemophilia patients: Results of the haemophilia-specific quality of life index in Korea [O] . Hee Jo Baek, Young Shil Park, Ki Young Yoo, 2020

机译：与中等和严重的血友病患者的健康有关的生活质量：韩国血友病患者的生活指数质量的结果
7. Assessing the effectiveness and cost-effectiveness of prophylaxis against bleeding in patients with severe haemophilia and severe von Willebrand's disease [O] . A. H. Miners, C. A. Sabin, K. H. Tolley, 1998

机译：评估预防血腥患者患者出血的有效性和成本效益和严重的冯维尔布朗疾病
8. Coalitions and Competition in Resource Development: An Example of Multi-Goal Programming Moderated by Multi-Person Games [R] . Charnes, A., Sorensen, S. 1972

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Turning severe into moderate haemophilia by prophylaxis: are we reaching our goal?

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