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Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2

机译:内在无序区域的磷酸化调节Neurogenin2的活性。

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摘要

BackgroundNeuronal differentiation is largely under the control of basic Helix-Loop-Helix (bHLH) proneural transcription factors that play key roles during development of the embryonic nervous system. In addition to well-characterised regulation of their expression, increasing evidence is emerging for additional post-translational regulation of proneural protein activity. Of particular interest is the bHLH proneural factor Neurogenin2 (Ngn2), which orchestrates progression from neural progenitor to differentiated neuron in several regions of the central nervous system. Previous studies have demonstrated a key role for cell cycle-dependent multi-site phosphorylation of Ngn2 protein at Serine-Proline (SP) sites for regulation of its neuronal differentiation activity, although the potential structural and functional consequences of phosphorylation at different regions of the protein are unclear.
机译:背景神经元分化在很大程度上受基本螺旋-螺旋-螺旋(bHLH)前神经转录因子的控制,这些转录因子在胚胎神经系统发育过程中起关键作用。除了对它们的表达进行充分表征的调节之外,对于前体蛋白活性的其他翻译后调节,越来越多的证据正在出现。特别令人感兴趣的是bHLH神经元因子Neurogenin2(Ngn2),它在中枢神经系统的多个区域协调从神经祖细胞到分化神经元的进程。先前的研究已证明,在丝氨酸脯氨酸(SP)位点,Ngn2蛋白的细胞周期依赖性多位点磷酸化对于调节其神经元分化活性具有关键作用,尽管在该蛋白不同区域磷酸化的潜在结构和功能后果还不清楚。

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