Correlation between blood magnesium and calcium concentration in patients treated with an anti-EGFR antibody

机译：抗EGFR抗体治疗的患者血镁与钙浓度的相关性

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BackgroundHypomagnesemia is one of the characteristic side effects of the human anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, cetuximab and panitumumab.The major mechanism of anti-EGFR antibody-related hypomagnesemia is suppression of EGFR-mediated urinary Mg²⁺ reabsorption in both the renal tubule the intestinal tract.Since Mg²⁺ is known to affect blood Ca²⁺ levels through regulation of parathyroid hormone (PTH) secretion, we investigated the correlation between Ca²⁺ and Mg²⁺ concentration in blood.

机译：背景低镁血症是人类抗表皮生长因子受体（EGFR）单克隆抗体西妥昔单抗和帕尼单抗的典型副作用之一。抗EGFR抗体相关的低镁血症的主要机制是抑制EGFR介导的尿Mg ^{2 + 在肾小管和肠道的重吸收。已知Mg ^{2 + 通过调节甲状旁腺激素（PTH）影响血液Ca ^{2 + 的水平我们研究了血液中Ca ^{2 + 与Mg ^{2 + 浓度之间的相关性。}}}}}

著录项

期刊名称 Journal of Pharmaceutical Health Care and Sciences
作者
Toshiyasu Tsujii; Takafumi Ogaki; Kaori Nakae; Kiyotaka Imai; Daisuke Kise; Shoji Tada; Hiroki Ueda; Masahiro Moriyama;
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作者单位

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年(卷),期 2016(2),-1
年度 2016
页码 23
总页数 6
原文格式 PDF
正文语种
中图分类药学;
关键词
Hypomagnesemia Calcium EGFR-targeting antibodies Cetuximab Panitumumab;

机译：低镁血症;钙;EGFR靶向抗体;西妥昔单抗;帕尼单抗;
入库时间 2022-08-17 11:48:27

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专利

1. Correlation between blood magnesium and calcium concentration in patients treated with an anti-EGFR antibody [J] . Toshiyasu Tsujii, Takafumi Ogaki, Kaori Nakae, Journal of Pharmaceutical Health Care and Sciences . 2016,第1期

机译：抗EGFR抗体治疗的患者血镁与钙浓度的相关性
2. Scientific Opinion on the substantiation of health claims related to fructooligosaccharides (FOS) from sucrose and decreasing potentially pathogenic gastro intestinal microorganisms (ID 774), changes in short chain fatty acid (SCFA) production and pH in the gastro‐intestinal tract (ID 775), changes in bowel function (ID 775, 778), reduction of gastro intestinal discomfort (ID 775, 778), increase in calcium and/or magnesium absorption leading to an increase in magnesium and/or calcium retention (ID 776, 777), maintenance of normal blood LDL cholesterol concentrations (ID 805) and maintenance of normal (fasting) blood concentrations of triglycerides (ID 805) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2011,第4期

机译：关于证实来自蔗糖的低聚果糖（FOS）和减少潜在致病性胃肠道微生物（ID 774），短链脂肪酸（SCFA）产量和胃肠道pH（ID 775）变化的健康主张的科学意见，肠功能的改变（ID 775、778），肠胃不适的减轻（ID 775、778），钙和/或镁吸收的增加导致镁和/或钙retention留的增加（ID 776、777），根据法规（EC）第1924/2006号第13（1）条，维持正常血液LDL胆固醇浓度（ID 805）和维持正常（禁食）甘油三酸酯浓度（ID 805）
3. Scientific Opinion on the substantiation of health claims related to “wheat dextrin” and maintenance of normal blood pressure (ID 844, 1682), maintenance of normal (fasting) blood concentrations of triglycerides (ID 844, 1682), maintenance of normal blood cholesterol concentrations (ID 844, 1682), reduction of post‐prandial glycaemic responses (ID 845, 3096), increase in magnesium and/or calcium retention (ID 846, 3097), short chain fatty acid (SCFA) production in the bowel (ID 1681), decreasing potentially pathogenic gastro‐intestinal microorganisms (ID 843, 1681) and maintenance of normal bowel function (ID 843, 1680) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J] . EFSA Journal . 2010,第10期

机译：关于“小麦糊精”和维持正常血压（ID 844、1682），维持甘油三酸酯正常（空腹）血药浓度（ID 844、1682），维持正常胆固醇水平的健康主张的科学意见（ID 844，1682），降低餐后血糖反应（ID 845、3096），增加镁和/或钙calcium留（ID 846、3097），肠中短链脂肪酸（SCFA）的产生（ID 1681）），根据（EC）1924/2006号法规第13（1）条，减少潜在致病性的胃肠道微生物（ID 843，1681）并维持正常肠功能（ID 843，1680）
4. Effects of postpartum calcium treatment on blood calcium concentration [C] . C.D.Blanc, Mark van derList, Sharif S. Aly, Annual Conference of the American^Association^of^Bovine^Practitioners. . 2014

机译：产后钙处理对血钙浓度的影响
5. Calcium/magnesium ratio and water potential effects on forage quality and pectin concentration. [D] . Prasad, Rishi. 2010

机译：钙/镁比和水势对饲草质量和果胶浓度的影响。
6. Correlation between manifestations of digoxin toxicity and serum digoxin calcium potassium and magnesium concentrations and arterial pH. [O] . M Sonnenblick, A S Abraham, Z Meshulam, 1983

机译：地高辛毒性表现与血清地高辛钙钾镁浓度和动脉pH的相关性。
7. Correlation between blood magnesium and calcium concentration in patients treated with an anti-EGFR antibody [O] . 2016

机译：抗EGFR抗体治疗的患者血镁与钙浓度的相关性

Correlation between blood magnesium and calcium concentration in patients treated with an anti-EGFR antibody

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