Searching joint association signals in CATIE schizophrenia genome-wide association studies through a refined integrative network approach

摘要

BackgroundGenome-wide association studies (GWAS) have generated a wealth of valuable genotyping data for complex diseases/traits. A large proportion of these data are embedded with many weakly associated markers that have been missed in traditional single marker analyses, but they may provide valuable insights in dissecting the genetic components of diseases. Gene set analysis (GSA) augmented by protein-protein interaction network data provides a promising way to examine GWAS data by analyzing the combined effects of multiple genes/markers, each of which may have only individually weak to moderate association effects. A critical issue in GSA of GWAS data is the definition of gene-wise P values based on multiple SNPs mapped to a gene.