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A combined linkage microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

机译：结合的连锁芯片和外显子组分析表明MAP3K11作为左心室肥大的候选基因

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BackgroundElectrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two principal components derived from them.

机译：背景技术左心室肥大（LVH）的心电图测量可作为心血管风险的预测指标。我们结合联系和关联分析，以发现涉及三种此类措施和从中衍生出的两个主要成分的新型罕见遗传变异。

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期刊名称 BMC Medical Genomics
作者
Claudia Tamar Silva; Irina V. Zorkoltseva; Maartje N. Niemeijer; Marten E. van den Berg; Najaf Amin; Ayşe Demirkan; Elisa van Leeuwen; Adriana I. Iglesias; Laura B. Piñeros-Hernández; Carlos M. Restrepo; Jan A. Kors; Anatoly V. Kirichenko; Rob Willemsen; Ben A. Oostra; Bruno H. Stricker; André G. Uitterlinden; Tatiana I. Axenovich; Cornelia M. van Duijn; Aaron Isaacs;
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年(卷),期 2018(11),-1
年度 2018
页码 22
总页数 10
原文格式 PDF
正文语种
中图分类遗传学;
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1. A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy [J] . Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, BMC Medical Genomics . 2018,第1期

机译：结合的连锁，芯片和外显子组分析表明MAP3K11作为左心室肥大的候选基因
2. Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing [J] . Claudio Toma, Marcos Díaz-Gay, Yasmin Soares de Lima, Clinical and Translational Gastroenterology . 2019,第10期

机译：通过执行连锁分析与全外显子测序相结合的锯齿状息肉综合征生殖细胞倾向性的新候选基因的鉴定。
3. Trial suggests that combining eplerenone and enalapril reduces left ventricular hypertrophy in hypertension more effectively than either treatment alone [J] . Evidence-based cardiovascular medicine Evidence-based cardiovascular medicine . 2004,第1期

机译：试验表明，依普利酮和依那普利联合使用比单独使用任何一种治疗方法都能更有效地减轻高血压左室肥大
4. Progression of left ventricular wall thickness during pressure-overload left ventricular hypertrophy [C] . Minjie Feng, Li, J.K.-J., . 2002

机译：压力超负荷时左心室肥厚过程中左心室壁厚度的变化
5. Association of high-sensitivity cardiac troponin,fibroblast growth factor 23 and left ventricular hypertrophy in Japanese patients with reduced renal function [D] . 伊藤, 敦巳 2019

机译：肾功能减退的日本人高敏感性心肌肌钙蛋白，成纤维细胞生长因子23与左心室肥厚的关系
6. Identification of a Novel Candidate Gene for Serrated Polyposis Syndrome Germline Predisposition by Performing Linkage Analysis Combined With Whole-Exome Sequencing [O] . Claudio Toma, Marcos Díaz-Gay, Yasmin Soares de Lima, 2019

机译：通过执行连锁分析与全外显子测序相结合的锯齿状息肉综合征生殖系易感性的新候选基因的鉴定。
7. P235Relation between myocardial deformation by three-dimensional speckle tracking analysis , control of the hypertension and functional capacity in patients with systemic hypertensionP236Obstructive sleep apnoea is often under-recognised in patients with acute myocardial infarction, but commonly contributes to left ventricular diastolic dysfunctionP237Intrinsic left ventricular dysfunction in Behcet disease in comparison with systemic disease activity: insights from speckle tracking echocardiographyP238Echocardiography changes during singleton and twin pregnancyP239Proposal of two new echocardiographic parameters for the differentiation of pre-capillary from post-capillary pulmonary hypertensionP240The coincidence of implanted device and number of electrodes with the presence of residual fibrotic tissue after transvenous leads extraction assessed in echocardiographic examP241Hemoglobin is an independent predictor of left ventricular hypertrophy in postmenopausal women but not in premenopausal womenP242Left ventricular longitudinal deformation impairment in patients with psoriasis is linked with immunologic activationP243Impaired diastolic functions and left atrial mechanical functions in patients with vitamin-D deficiencyP244Modification of cardiac and vascular function secondary to insulin resistanceP245Impaired right ventricular function is not related to serum galectin-3 concentration in patients with repaired tetralogy of fallotP246Age-adjusted indices of right ventricular (RV) longitudinal function do not adequately reflect the global RV contraction in children with repaired congenital heart defects and RV volume overloadP247Relationship between fractional flow reserve and dobutamine stress echocardiography in coronary artery diseaseP248A retrospective observational comparative study on the negative predictive value of nuclear testing vs. stress echo in pre-operative assessment for patients undergoing solid organ transplantionP249The detection of viable myocardium by dobutamine stress speckle tracking echocardiography in patients with coronary artery diseaseP250VO2 flattening during exercise in heart failure: evidence for a combined low cardiac output and inefficient O2 extractionP251 The dynamic assessment of alveolar-capillary barrier during exercise-echocardiography in heart failure patients with reduced ejection fractionP252The effect of exercise training on cardiac function during exercise stress echo in patients with type 2 diabetes and diastolic dysfunctionP253Age-related maximal exercise O2 extraction differences in a population of apparently healthy subjects at cardiovascular riskP254Difference in the changes of functional mitral regurgitation between semisupine ergometer and handgrip exerciseP255Correlation of annulus size assessed by echo 2d, 3d and multidetector computed tomography in patients undergoing transcatheter aortic valve implantationP256Mitral annulus dynamics: from normal to extensive mixomatous disease-a three-dimensional transoesophageal studyP257Left atrial appendage closure: an echo point of view of 55 casesP258Effect of catheter-based renal denervation on left ventricular function, mass and (un)twist with two-dimensional speckle tracking echocardiographyP259Associations of microRNAs gene expression in peripheral blood mononuclear cells and left ventricular global longitudinal peak strain in patients with essential hypertension [O] . I. Craciunescu, N. Ngiam, BJ. Sun, 2016

机译：心肌变形之间P235Relation通过三维斑点追踪分析，在患者全身hypertensionP236Obstructive睡眠呼吸暂停的高血压和功能的能力控制是经常根据公认在急性心肌梗死，但通常有助于左室舒张dysfunctionP237Intrinsic左心室功能紊乱中白塞氏病与全身性疾病的活性的比较：用于预毛细管的从植入装置和电极数目的毛细血管后肺hypertensionP240The巧合的分化与存在的两个新的超声心动图参数单和双pregnancyP239Proposal期间从斑点追踪echocardiographyP238Echocardiography变化的见解静脉引线后残留的纤维组织提取评估了超声心动图examP241Hemoglobin是绝经后妇女的左心室肥厚的独立预测因素，但不是在premen opausal womenP242Left心室纵向变形损害牛皮癣患者与免疫联activationP243Impaired舒张功能和左心房机械功能患者的心脏和血管功能继发于胰岛素的维生素-d deficiencyP244Modification resistanceP245Impaired右心室功能是不相关的血清半乳凝素3浓度患者右心室（RV）的纵向功能fallotP246Age调整指标的修复四部曲没有充分反映在冠状动脉diseaseP248A追溯血流储备分数和多巴酚丁胺超声心动图之间修复先天性心脏缺陷和RV容积overloadP247Relationship全球儿童RV收缩在术前评估核试验对应力回声的阴性预测值进行可行myocard的实体器官transplantionP249The检测患者的观察对比研究鎓通过多巴酚丁胺斑点跟踪超声心动图在患者的心脏衰竭锻炼期间冠状动脉diseaseP250VO2压扁：证据为一个组合的低心输出量和低效率的O2 extractionP251在心脏衰竭患者运动超声心动图中肺泡 - 毛细血管屏障的动态评估具有降低的喷射对心脏功能的运动锻炼的运动负荷超声过程中患者fractionP252The影响2型糖尿病患者和表面健康受试者的群体在心血管riskP254Difference在功能性二尖瓣返流的semisupine测力计和手柄之间的变化舒张dysfunctionP253Age相关的最大运动O2提取差异环大小的exerciseP255Correlation由回波2D评估，3d和多排的患者正在接受经导管主动脉瓣implantationP256Mitral环动力学计算机断层：从正常到广泛mixomatous疾病三dimensi Onal地区食道studyP257Left心耳闭合：视在左心室功能，质量和（UN）捻基于导管的肾去神经支配的55 casesP258Effect的在外周血单核细胞和左侧的微小RNA基因表达的二维散斑跟踪echocardiographyP259Associations回波点心室全球纵向应变峰值在原发性高血压患者

A combined linkage microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

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