Evaluation of expression and function of vascular endothelial growth factor receptor 2 platelet derived growth factor receptors-alpha and -beta KIT and RET in canine apocrine gland anal sac adenocarcinoma and thyroid carcinoma

摘要

BackgroundToceranib phosphate (Palladia) has a reported objective response rate of 25% in both canine apocrine gland anal sac adenocarcinoma (AGASACA) and thyroid carcinoma (TC), with stable disease occurring in an additional 50-60% of dogs. The basis for the observed responses to toceranib is not known. The purpose of this study was to evaluate AGASACA and TC samples for the expression and activation of VEGFR2, PDGFRα, PDGFRβ, KIT and RET to assess whether dysregulation of these receptor tyrosine kinases (RTKs) may contribute to the biologic activity of toceranib.