A total of 104 eyes undergoing intraocular surgery were studied to investigate the effect on intraocular pressure (IOP) of peribulbar and retrobulbar anaesthesia in eyes with and without glaucoma. Forty eyes had glaucoma. Intraocular pressure was measured before, immediately after, and 5 minutes after injection of local anaesthetic. Mean IOP rose by 5.8 mm Hg at 1 minute (p < 0.01) and 0.7 mm Hg at 5 minutes (p > 0.05). However, in eyes not receiving external ocular compression after the 1 minute measurement (n = 70, 67%), IOP was still 3.6 mm Hg higher than baseline (p < 0.01), compared with 5.2 mm Hg lower than baseline (p < 0.01) where compression was used. Patients with glaucoma experienced higher and more persistent increases in IOP than those without glaucoma. The increase in IOP varied greatly between patients: the maximum rise was 25 mm Hg, and in one glaucoma patient an IOP of 50 mm Hg occurred, persisting for 5 minutes. At 1 minute, 14 of the glaucoma subjects (35%) had experienced an IOP rise of > or = 10 mm Hg, and four (10%) a rise of > or = 20 mm Hg. These results suggest that the changes in IOP in patients with glaucoma, with an acute increase in IOP being succeeded by an acute decrease on entry into the anterior chamber, may be hazardous. The implications for clinical practice are discussed.
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机译：研究了总共104眼进行眼内手术的眼睛，以研究在有和没有青光眼的情况下眼球周围和眼球后麻醉对眼内压（IOP）的影响。四十眼有青光眼。在注射局部麻醉剂之前，之后和之后5分钟测量眼内压。平均IOP在1分钟时上升5.8 mm Hg（p <0.01），在5分钟时上升0.7 mm Hg（p> 0.05）。但是，在测量1分钟后未接受外眼压迫的眼睛中（n = 70，67％），IOP仍比基线高3.6 mm Hg（p <0.01），而比基线低5.2 mm Hg（p <0.01） ）使用压缩。青光眼患者的眼压高于无青光眼患者。患者之间的眼压升高差异很大：最大升高为25毫米汞柱，一名青光眼患者的眼压升高为50毫米汞柱，持续5分钟。在1分钟时，有14名（35％）青光眼受试者的IOP升高≥10 mm Hg，四名（10％）IOP升高≥20 mm Hg。这些结果表明，青光眼患者眼压的变化可能是危险的，眼压急剧增加可通过进入前房的急剧减少而继发。讨论了对临床实践的意义。
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