Gastrointestinal transit release and plasma pharmacokinetics of a new oral budesonide formulation

机译：一种新型布地奈德口服制剂的胃肠道转运释放和血浆药代动力学

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摘要

AimsThe aims of the study were to: (1) evaluate the gastrointestinal transit, release and absorption of budesonide from tablets with a new multimatrix formulation (MMX®) designed to release the drug throughout the whole colon, and (2) assess the influence of food on budesonide bioavailability.

机译：目的本研究的目的是：（1）通过设计用于在整个结肠内释放药物的新型多基质制剂（MMX®）评估布地奈德从片剂的胃肠道转运，释放和吸收，以及（2）评估以下药物的影响食物对布地奈德的生物利用度。

著录项

期刊名称 British Journal of Clinical Pharmacology
作者
M Brunner; S Ziegler; A F D Di Stefano; P Dehghanyar; K Kletter; M Tschurlovits; R Villa; R Bozzella; G Celasco; L Moro; A Rusca; R Dudczak; M Müller;
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作者单位

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年(卷),期 2006(61),1
年度 2006
页码 31–38
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
budesonide gastrointestinal transit targeted drug delivery pharmaco-scintigraphy food effect;

机译：布地奈德;胃肠道转运;靶向给药;药理学扫描;食品效应;

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专利

1. Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation. [J] . Brunner M, Ziegler S, Di Stefano AF, British Journal of Clinical Pharmacology . 2006,第1期

机译：一种新的布地奈德口服制剂的胃肠道转运，释放和血浆药代动力学。
2. Plasma pharmacokinetics and gastrointestinal transit of a new propionyl-L-carnitine controlled release formulation. [J] . Wagner CC, Rusca A, Kletter K, Xenobiotica: the fate of foreign compounds in biological systems . 2011,第11期

机译：一种新的丙酰-L-肉碱控释制剂的血浆药代动力学和胃肠道转运。
3. Pharmacokinetic modeling and simulation of gastrointestinal transit effects on plasma concentrations of drugs from mixed immediate-release and enteric-coated pellet formulations. [J] . Watanalumlerd P, Christensen JM, Ayres JW Pharmaceutical development and technology . 2007,第2期

机译：胃肠道转运对速溶和肠溶微丸混合制剂中血浆浓度的影响的药代动力学建模和模拟。
4. PHARMACOKINETIC EVALUATION OF KETOROLAC TROMETHAMINE SUSTAINED-RELEASE PELLET FORMULATION AFTER ORAL ADMINISTRATION IN BEAGLE DOGS [C] . Guk Hyun Jo, Sung-Joo Hwang, Sun Hang Cho Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：小剂量口服给药后酮咯酸对苯三胺缓释微丸制剂的药动学评价
5. 1. Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications. 2. Development of crushable enteric-coated formulations. 3. Development of leaky enteric-coated pellets formulations. [D] . Watanalumlerd, Prapoch. 2004

机译：1.胃肠道转运对肠溶微丸制剂中药物药代动力学的影响的药代动力学建模和模拟及其应用。 2.开发可压碎的肠溶衣制剂。 3.开发泄漏的肠溶丸剂。
6. Comparison of the pharmacokinetics of an oral extended‐release capsule formulation of carbidopa‐levodopa (IPX066) with immediate‐release carbidopa‐levodopa (Sinemet®) sustained‐release carbidopa‐levodopa (Sinemet® CR) and carbidopa‐levodopa‐entacapone (Stalevo®) [O] . Ann Hsu, Hsuan‐Ming Yao, Suneel Gupta, -1

机译：口服卡比多巴-左旋多巴（IPX066）与速释卡比多巴-左旋多巴（Sinemet®）缓释卡比多巴-左旋多巴（Sinemet®CR）和卡比多巴-左旋多巴-entacapone（ Stalevo®）
7. Gastrointestinal transit, release and plasma pharmacokinetics of a new oral budesonide formulation [O] . Brunner, M, Ziegler, S, Di Stefano, A F D, 2006

机译：一种新型布地奈德口服制剂的胃肠道转运，释放和血浆药代动力学

Gastrointestinal transit release and plasma pharmacokinetics of a new oral budesonide formulation

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