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Host microenvironment in breast cancer development: Epithelial-cell–stromal-cell interactions and steroid hormone action in normal and cancerous mammary gland

机译:乳腺癌发展中的宿主微环境:正常和癌性乳腺中的上皮细胞-基质细胞相互作用和类固醇激素作用

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摘要

Mammary epithelial cells comprise the functional component of the normal gland and are the major target for carcinogenesis in mammary cancer. However, the stromal compartment of the normal gland and of tumors plays an important role in directing proliferative and functional changes in the epithelium. In vivo and in vitro studies of the murine mammary gland have provided insights into novel stroma-dependent mechanisms by which estrogen and progesterone action in the epithelium can be modulated by hepatocyte growth factor (HGF) and the extracellular matrix proteins, collagen type I, fibronectin and laminin. In vitro and in vivo studies of estrogen receptor positive, estrogen-responsive human breast cancer cells have also demonstrated that estrogen responsiveness of tumor cells can also be modulated by extracellular matrix proteins, collagen type I and laminin.
机译:乳腺上皮细胞包含正常腺体的功能成分,是乳癌致癌作用的主要靶标。然而,正常腺和肿瘤的基质区隔在指导上皮细胞的增殖和功能变化中起重要作用。小鼠乳腺的体内和体外研究为新的基质依赖性机制提供了见识,通过这种机制,上皮中的雌激素和孕激素作用可被肝细胞生长因子(HGF)和细胞外基质蛋白,I型胶原,纤连蛋白调节和层粘连蛋白。雌激素受体阳性,雌激素反应性人乳腺癌细胞的体外和体内研究也表明,肿瘤细胞的雌激素反应性也可以通过细胞外基质蛋白,I型胶原和层粘连蛋白来调节。

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