Expression pattern of the apoptosis-stimulating protein of p53 family in p53+ human breast cancer cell lines

摘要

BackgroundThe apoptosis-stimulating protein of p53 (ASPP) family comprises three members, namely, ASPP1, ASPP2, and iASPP. They regulate the promotive effect of p53 on apoptosis. Breast cancer (BC) remains as one of the leading causes of cancer or cancer-related mortality among women. However, the relationship between the ASPP family members and p53, as well as the dissemination and expression pattern of ASPP family members in p53⁺ BC, has not been elucidated. Our objectives are to detect the expression of ASPP family members in p53⁺ BC cell lines and determine its significance in tumor cell apoptosis.