Functional Changes in Acute Eosinophilic Myocarditis Due to Chemotherapy With Ibrutinib

摘要

class="kwd-title">Keywords: Myocarditis, Left ventricular wall thickness, Strain class="head no_bottom_margin" id="sec1title">IntroductionDifferential diagnosis of increased left ventricular (LV) wall thickness includes hypertensive heart disease, aortic valve stenosis, hypertrophic cardiomyopathy, and infiltrative cardiomyopathies such as cardiac amyloidosis (CA), all of them chronic conditions. Differentiating CA from other causes of increased LV wall thickness is important because it often carries a dismal prognosis if not treated. Although other conditions may mimic CA, recent advances in imaging such as myocardial strain, cardiac magnetic resonance imaging (MRI), and nuclear imaging have proved very helpful in discriminating CA from other causes of increased LV wall thickness. Nonetheless, despite sensitivities and specificities of findings such as apical sparing in myocardial strain, late gadolinium enhancement, and short inversion time in T1 mapping on cardiac MRI, as well as radiotracer accumulation on nuclear imaging, often a tissue diagnosis is necessary to confirm the diagnosis of CA.As mentioned before, an increase in LV wall thickness is not necessarily due to chronic disease, as acute processes such as ischemia with reperfusion and inflammation can lead to myocardial swelling. Here, we describe a case of acute myocarditis that presented with increased LV wall thickness and demonstrated various imaging features mimicking infiltrative cardiomyopathy.