A Case of a Full-Term Infant With Symptomatic Patent Ductus Arteriosus Successfully Closed With Indomethacin Treatment: Consideration of Mechanism for Ductus Arteriosus Closure

摘要

class="kwd-title">Keywords: Patent ductus arteriosus, Full-term infant, Indomethacin, Prostaglandin class="head no_bottom_margin" id="sec1title">IntroductionPatent ductus arteriosus (PDA) accounts for approximately 5% to 10% of all congenital heart diseases. Most cases of PDA are diagnosed and treated from infancy through childhood, but those clinically diagnosed in adulthood also are not rare. Basically, the presence of a heart murmur and symptomatic cases are considered to be indications for PDA treatment. If medical management does not lead to PDA closure, then indomethacin (IND) is administered intravenously, mainly in preterm infants., However, the effectiveness of IND injection in full-term infants with PDA remains undetermined. We herein report our experience with a 12-day-old, full-term infant with symptomatic PDA successfully treated with IND therapy.