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Phylogenetic analysis of three orf virus strains isolated from differentdistricts in Shandong Province East China

机译:从不同菌株分离出的三株orf病毒株的系统发育分析华东地区山东省

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摘要

Orf virus (ORFV) is the causative agent of contagious ecthyma, which is a zoonotic disease that affects sheep, goats, wild small ruminants and humans. Shandong Province in East China is one of the main producing areas in China for sheep and goats. Here, we conducted epidemiological surveys in different areas in this Province, isolated three orf virus strains, SDLC, SDTA and SDJN, from goat flocks and then analyzed the genetic evolution of these strains. The ORFV011, ORFV059, ORFV109, ORFV110 and ORFV127 genes of these three strains were amplified, sequenced and analyzed. Phylogenetic analysis showed that ORFV011 of the SDLC and SDTA strains cluster together with the Gansu, Liaoning, Shanxi, Nantou, Hoping and FJ-YX strains, while SDJN clusters with the FJ-GS and FJ-GO strains. ORFV059 of the SDLC and SDTA strains cluster together with the FJ-YX strain, while SDJN clusters with the FJ-GS and FJ-GO strains. ORFV059 and ORFV127 of these three strains were similar to those of the OV-SA00 strain. The results suggested that SDLC, SDTA and SDJN originated from Fujian Province and formed a complex group of viruses in Shandong Province. As the role of ORFV127 gene responsible for the immune evasion of ORFV, the pathogenesis of these three virus strains may similar to that of OV-SA00.These three strains first isolated in Shandong Province are novel ORFV strains, and thedata reported here will be helpful for further research about ORFV and its comprehensiveprevention and control.
机译:Orf病毒(ORFV)是传染性蜕膜炎的病原体,这是一种人畜共患病,影响绵羊,山羊,野生小反刍动物和人类。中国东部的山东省是中国绵羊和山羊的主要产区之一。在这里,我们在该省的不同地区进行了流行病学调查,从山羊群中分离出3种orf病毒株SDLC,SDTA和SDJN,然后分析了这些株的遗传进化。扩增,测序和分析这三个菌株的ORFV011,ORFV059,ORFV109,ORFV110和ORFV127基因。系统发育分析表明,SDLC和SDTA菌株的ORFV011与甘肃,辽宁,山西,南投,霍普和FJ-YX菌株一起聚集,而SDJN与FJ-GS和FJ-GO菌株一起聚集。 SDLC和SDTA菌株的ORFV059与FJ-YX菌株聚集在一起,而SDJN与FJ-GS和FJ-GO菌株聚集在一起。这三个菌株的ORFV059和ORFV127与OV-SA00菌株相似。结果表明,SDLC,SDTA和SDJN起源于福建省,在山东省形成了复杂的病毒群。由于ORFV127基因负责ORFV的免疫逃逸,这三种病毒株的发病机理可能与OV-SA00相似。山东省首次分离到的这3个菌株是新型ORFV菌株,此处报告的数据将有助于进一步研究ORFV及其综合预防和控制。

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