Urinary proteomic shotgun approach for identification of potential acute rejection biomarkers in renal transplant recipients

摘要

BackgroundAcute rejection (AR) episodes in renal transplant recipients are suspected when plasma creatinine is elevated and other potential causes out ruled. Graft biopsies are however needed for definite diagnosis. Non-invasive AR-biomarkers is an unmet clinical need. The urinary proteome is an interesting source in the search for such a biomarker in this population.